I have TRD and CP and was getting good effect from 4x5mg Oxycodone for about 2 years. It helped a bit with the chronic pain but more importantly it helped with the truly traumatic anhedonia and depression I suffer. I would get a solid 45 minutes of “normality” from each dose - I’d actually care about things. Obviously I never mentioned this to my pain doctor.
However in Feb I had an SCS implant operation which went a bit wrong and left me in a lot of nerve pain (thoracic radiculopathy - a pinched nerve, of sorts). They prescribed extra oxycodone, which let me have a great February mood-wise but now 5mg, or even 20mg oxycodone leaves me feeling empty and anhedonic. The obvious conclusion is that my tolerance has shot up.
This is personally totally devastating as those 45 minutes of normality allowed me to connect with Normal humans, to feel human, to feel... alive. Not high - just normally alive.
Anyway, my question is: is it possible to get the oxycodone response/effect on mood back? If so, what is the best way to do that? Taper down to 0mg? Taper to 10mg? If so, for how long? How quickly should I taper back up? - I’ve no idea.
If anyone could shed any light or pointers on this area, I’d be extremely grateful.
Be well as well as you can,